| 摘要 |
<p>An extracorporeal blood circulation system for treating inflammatory diseases, comprising blood collection means for collecting blood from a patient suffering from an inflammatory disease, anticoagulant mixing means for mixing an anticoagulant into the collected blood, blood transportation means for transporting the anticoagulant-containing blood at a flow rate in the range of from 20 to 200 ml/minute, blood treating means having a blood inlet and a blood outlet and containing platelet activating means, and blood returning means for returning the treated blood to the patient, wherein these means are liquid-tightly connected in this order through a tubing, and wherein, when extracorporeal blood circulation is conducted using the system with respect to blood from the patient, the system is capable of providing treated blood satisfying at least one requirement selected from requirement (1) of having a beta -thromboglobulin concentration in the range of from 1,000 to 20,000 ng/ml and requirement (2) of having a platelet factor 4 concentration in the range of from 500 to 10,000 ng/ml. Also disclosed is an extracorporeal blood circulation method which provides treated blood in which platelets are activated to a specific degree that the above-mentioned requirement (1) and/or requirement (2) is satisfied. The extracorporeal blood circulation system and method of the present invention can achieve a high therapeutic effect on inflammatory diseases, as compared to a therapeutic effect achieved by conventional extracorporeal blood circulation therapies.</p> |
