Preparation of 3-oxy-5-oxo-6-heptenoic acid derivatives

摘要

Methyl (3R, 6E)-3-[(tert-butyldimethylsilyl)oxy]-7-[2', 6'-diisopropyl-4'-(4''-fluorophenyl)-5'-(methoxymethyl)pyridin-3'-yl]-5-oxy-6-heptenoate or other 3-oxy-5-oxo-6-heptenoic acid derivative is prepared by the reaction of an aromatic aldehyde and an oxyglutaric acid derivative in an aliphatic alcohol containing a small amount of water in the presence of an alkali metal carbonate or hydrogen carbonate.