| 摘要 |
PCT No. PCT/JP96/02535 Sec. 371 Date May 1, 1997 Sec. 102(e) Date May 1, 1997 PCT Filed Sep. 6, 1996 PCT Pub. No. WO97/09312 PCT Pub. Date Mar. 13, 1997The present invention is directed to methods for manufacturing 3-(aminomethyl)-6-chloropyridines represented by a general formula [II]; <IMAGE> [II] wherein R2 represents hydrogen or a lower alkyl and R3 represents hydrogen, a lower alkyl or an halogen atom, characterized in that the compound represented by the general formula [II] is manufactured by allowing 3-(substituted-aminomethyl)pyridine 1-oxide represented by a general formula [I]; <IMAGE> [I] wherein R1 represents alkyl, aryl, aralkyl or alkoxy, R2 and R3 are as described above, to react with a base represented by a general formula [a]; R'R''R'''N [a]wherein R', R'' and R''' may be the same or different one another and represent each independently a lower alkyl or an aromatic group, or R', R'' , R''' and N may form together an optionally-substituted pyridine ring, in the presence of an electrophilic reagent having at least one chlorine atom, and subsequently treating the reaction product with hydrogen chloride and water. The compounds manufactured according to the present invention are useful as the raw materials used for the manufacturing of agricultural chemicals and pharmaceuticals, and particularly useful for the raw materials for manufacturing insecticides.
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