发明名称 |
HUMAN DNASE I VARIANTS |
摘要 |
The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I. |
申请公布号 |
HUT77422(A) |
申请公布日期 |
1998.04.28 |
申请号 |
HU19980000180 |
申请日期 |
1995.02.24 |
申请人 |
GENENTECH INC. |
发明人 |
LAZARUS,ROBERT A.;SHAK,STEVEN;ULMER,JANA S. |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61P11/00;A61P11/08;A61P11/12;C12N;C12N9/16;C12N9/22;C12N15/55 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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