gamma -L-glutamyl containing immunomodulator compounds and methods therewith

摘要

The new class of synthetic immunomodulatory molecules having a gamma -L-glutamyl- moiety at the amino terminus are provided as illustrated by Formula 1. FORMULA 1 <IMAGE> In Formula 1, the Greek symbols designate the noted carbon atoms, R is hydrogen, acyl or alkyl, and X is an aromatic or heterocyclic amino acid or its derivative. Included as members of the new class (in addition to Bestim, gamma -L-glutamyl-L-tryptophan) are those compounds where R=hydrogen and X=L-tryptophan, such as gamma -L-glutamyl-Nin-formyl-L-tryptophan, N-methyl- gamma -L-glutamyl-L-tryptophan, N-acetyl- gamma -L-glutamyl-L-tryptophan, and gamma -L-glutamyl- beta -thienyl-D-alanylamide. A preferred embodiment, termed "BESTIM," has the chemical structure of gamma -L-glutamyl-L-tryptophan.