| 摘要 |
N-Aryl-piperazinealkaneamides (I) were prepd. by the reaction of (II) and (III) in the presence of basic(where X is hydroxy C1-4 alkyl, C1-4 alkyloxy, C1-4 alkyloxy carbonyl or aminocarbonyl; m is 1 or 2; R2is H or C1-4 alkyl; R3, R4 and R5 are H, hydroxy, C1-4 alkyl, C1-4 alkyloxy, trifluoromethyl or amino; Alk is C1-6 alkanediyl; Q is dihalophenylmethyl, phenyl or phenylmethyl; W is halo). (I) increase the oxygen tension (pO2) of coronary sinus venous blood on oral or i.v. admin.
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