PHENYL-SUBSTITUTED ALKENYLCARBOXYLIC GUANIZID, ITS PRODUCTION, ITS USE AS MEDICAL OR DIAGNOSTIC AGENT, AND PHARMACEUTICAL CONTAINING IT

摘要

PROBLEM TO BE SOLVED: To produce phenyl-substituted alkenylcarboxylic guanizid, which is a selective inhibitor of sodium/proton exchanger and can be used for treatment of arrhythmia, myocardial infarction, angina petoris, etc. SOLUTION: This phenyl-substituted alkenylcarboxylic guanizid of formula I [T is formula II [R(A) is H, a halogen, CN, etc.; R(B), R(C), and R(D) are each R(A); (x) and (y) are each 0-2; R(F) is H, a halogen, CN, etc.; R(E) is R(FF)], R(1) is T, H, a halogen, etc.; R(2)-R(5) are each R(1) or -CH-CH=CH- CH- in their combination, F, Cl, CF3 , etc.], for example, 1,2-bis(3-E-2- methylpropenic guanizid)]benzene dichloride, is obtained by a reaction of a compound of formula III (L is a nucleophilically replaceable eliminatory group with ganidine. This phenyl-substituted alkenylcarboxylic guanizid is effective for ischemic condition of heart, peripheral and central nerves, peripheral organs and extremities, shocks, etc.