| 摘要 |
PROBLEM TO BE SOLVED: To profitably obtain an amidothiophosphate useful as an insecticide, a nematocide, an acaricide, etc., by reacting a thiphosphoryl chloride compound with a carbamate compound in the presence of an alkali and a phase transfer catalyst in two phases comprising an organic solvent and water. SOLUTION: A thiophoshoryl chloride of formula I (R1 is methyl, ethyl; R2 is n-propyl, sec-butyl) (e.g. O-ethyl s-n-propylchlorophoshate) is reacted with a carbamate derivative of formula II (R3 is a 1-4C alkyl, phenyl) (e.g. ethyl N-cyanomethylcarbamate), in the presence of an alkali metal hydroxide (e.g. sodium hydroxide) and a phase transfer catalyst (e.g. tertrabutylammonium bromide) in two phase systems comprising an organic solvent (e.g. toluene) and water to profitably obtain the objective amidothiophoshate ester derivative of formula III useful as an insecticide, a nematocide, an acaricide, etc. |
