发明名称 |
9-N-ETHENYL DERIVATIVES OF 9(S)-ERYTHROMYCYLAMINE |
摘要 |
The invention relates to 9-N-ethenyl derivatives of 9(S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) (see fig. I) wherein R1 and R2 are the same or different and represent nitryl, a carboxyl gro up of the formula COOR3, wherein R3 represents a C1-C4 alkyl group, or a keto group of the formula COR4, wherein R4 represents a C1-C4 alkyl group, to their pharmaceut ically acceptable addition salts with inorganic or organic acids, to a process for thei r preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.
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申请公布号 |
CA2217417(A1) |
申请公布日期 |
1998.04.28 |
申请号 |
CA19972217417 |
申请日期 |
1997.10.27 |
申请人 |
PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DION ICKO DRUSTVO |
发明人 |
KUJUNDZIC, NEDJELJKO;LAZAREVKI, GORJANA;PAVLOVIC, DINA;KOBREHEL, GABRIJELA;KELNERIC, ZELJKO |
分类号 |
A61K31/70;A61K31/7042;A61K31/7048;A61P31/04;C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
A61K31/70 |
代理机构 |
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