| 摘要 |
<p>FIELD: medicine. SUBSTANCE: present invention describes compounds of formula (I): <EMI ID=0.350 HE=48 WI=21 TI=CHI> wherein A is group IIa, IIb or IIc: <EMI ID=0.351 HE=27 WI=39 TI=CHI>, <EMI ID=0.352 HE=27 WI=42 TI=CHI>, <EMI ID=0.353 HE=27 WI=33 TI=CHI> wherein R is alkyl, alkenyl, cycloalkyl or group of formula: R<SP>4</SP>-Y-R wherein R is hydrogen, alkyl or cycloalkyl; R is single bond or alkylene and Y is oxygen, sulfur or imino group; R is hydrogen, halogen optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, formyl, alkylcarbonyl, hydroxy, amino, alkylamino, dialkylamino, alkoxy, alkylthio, cyano or nitro group; R is hydrogen, alkyl, carboxy or substituted carboxy group, carbamoyl or tetrazol-5-yl; X is group of formula CH=, -N= or C(COOR) wherein R is hydrogen or protecting radical for carboxy group; Z is single bond, alkylene or vinylene and B is carboxy or substituted carboxy group or tetrazol-5-yl, and pharmaceutically acceptable salts and esters thereof are capable of inhibiting angiotensin and are useful for treatment and prophylaxis of hypertension and cardiac diseases. EFFECT: improved properties of the title compounds. 49 cl, 6 dwg , 3 tbl</p> |
