发明名称 |
Reconstituted human anti-hm1.24 antibody |
摘要 |
A reshaped human anti-HM 1.24 antibody comprising: (A) an L chain comprising (1) the C region of a human L chain, and (2) the V region of an L chain comprising the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain comprising (1) the C region of a human H chain, and (2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. Since most of this reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, the reshaped human antibody of the present invention has a low antigenicity and, therefore, is expected to be used for medical treatment. |
申请公布号 |
AU4399297(A) |
申请公布日期 |
1998.04.24 |
申请号 |
AU19970043992 |
申请日期 |
1997.10.03 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KOICHIRO ONO;TOSHIHIKO OHTOMO;MASAYUKI TSUCHIYA;YASUSHI YOSHIMURA;YASUO KOISHIHARA;MASAAKI KOSAKA |
分类号 |
C07K16/42;A61K38/00;A61K39/395;C07K16/28;C07K16/30;C12N1/15;C12N1/19;C12N1/21;C12N15/13;C12N15/63;C12P21/08 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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