| 摘要 |
The invention concerns a method for preparing a multi-particulate pharmaceutical form with controlled multi-sequential release for ensuring in the patient's organism a sufficient concentration of one or several active principles by one or two administrations in 24 hours. Said method is characterised in that the pharmaceutical form comprising at least two populations of particles different in their coating, is prepared, preferably continuously, inside only one single coating installation from a plurality of similar medicinal spheroids and one or several coating products, the plurality of medicinal spheroids being divided into as many fractions as the populations to be contained in the pharmaceutical form to be prepared. The resulting fractions of medicinal spheroids are successively inserted in the single coating installation to be subjected therein, except optionally the last one, to a coating by means of as many fractions of one or the other of said coating products, the coating of a given fraction of medicinal spheroids being carried out in the presence of the medicinal spheroids of the preceding fraction(s) which have already been subjected to coating. The plurality of medicinal spheroids thus treated constitute a whole which is then worked to constitute the desired pharmaceutical form. |
