| 摘要 |
<p>The invention relates to consolidated ligands, which include amino acid sequences which bind to at least two domains of a target protein. The consolidated ligands have increased affinity for the target protein over ligands directed to a single domain. Particularly preferred ligands include those directed to the Src Homology 2 and 3 (SH2, SH3) domains of eukaryotic protein tyrosine kinases, which are involved in complex regulation of the enzymic activity, obligatory for differentiation and growth control. Ligands of this kind of design may be widely useful as reagents in the investigation of SH interactions, and as leads for design of therapeutic agents.</p> |
