发明名称 |
PEPTIDE-LIPID CONJUGATES, LIPOSOMES AND LIPOSOMAL DRUG DELIVERY |
摘要 |
Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
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申请公布号 |
CA2276267(A1) |
申请公布日期 |
1998.04.23 |
申请号 |
CA19972276267 |
申请日期 |
1997.10.15 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
ERUKULLA, RAVI K.;FRANKLIN, J. CRAIG;CABRAL-LILLY, DONNA;PAK, CHARLES;MEERS, PAUL R.;JANOFF, ANDREW S.;ALI, SHAUKAT |
分类号 |
A61K9/127;A61K38/00;A61K47/48;C07K1/107;C07K5/06;C07K5/08;C07K5/083;C07K5/093;C07K5/097;C07K5/10;C07K5/103;C07K7/06;C07K9/00;(IPC1-7):A61K38/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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