发明名称 COMPOSITIONS AND METHODS FOR DETECTION OF ANTIBODY BINDING TO CELLS
摘要 The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on the surface of the bacteriophage, the first antibody being specific for an antigen-bearing moiety expressed by at least a portion of the cells in the cell population, wherein the first antibody binds to the portion of the cells causing the bacteriophage to also bind to the portion of the cells, adding to the mixture a second antibody specific for the bacteriophage, wherein binding of the second antibody to bacteriophage bound to the portion of the cells causes the portion of the cells to agglutinate or be captured.
申请公布号 WO9816827(A1) 申请公布日期 1998.04.23
申请号 WO1997US17995 申请日期 1997.10.10
申请人 THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 发明人 SIEGEL, DONALD, L.
分类号 G01N33/543;C07K16/08;C07K16/34;G01N33/553;(IPC1-7):G01N33/53;G01N33/541;G01N33/567;G01N33/574;C12P21/04;C12P21/06;C12P21/08;C12N7/00 主分类号 G01N33/543
代理机构 代理人
主权项
地址