| 摘要 |
<p>A pharmaceutically useful benzoxepine compound of formula (I), wherein R1 is 3-azetidinyl, 4-piperidyl or a group of the formula: -Y-NHR4, in which R4 is hydrogen or amino protective group, and Y is lower alkylene or cyclo(lower) alkylene; R2 is cyano and R3 is aryl; R2 is esterified carboxy and R3 is ar(lower)alkyl: or R?2 and R3¿ are linked together to form formula (a), in which R5 is acyl, A is -(CH¿2?)n-, in which n is 2, 3 or 4, vinylene or butenylene, X is bond or lower alkylene, and formula (b) is piperidino, and pharmaceutically acceptable salts thereof. The compound or a pharmaceutically acceptable salt thereof of the present invention has excellent promotion activity of growth hormone release for animals and human bodies.</p> |
