发明名称 |
STABLE GLASSY STATE POWDER FORMULATIONS |
摘要 |
A powdered, dispersible composition having stable dispersibility over time is provided. The composition exhibits a characteristic glass transition temperature (Tg) and a recommended storage temperature (Ts), wherein the difference between Tg and Ts is at least about 10 ~C (i.e. Tg-Ts is greater than 10 ~C). The composition comprises a mixture of a pharmaceuticallyacceptable glassy matrix and at least one pharmacologically active material within the glassy matrix. It may be further mixed with a powdered, pharmaceutically-acceptable carrier. It is particularly valuable in unit dosage form having a moisture barrier, in combination with appropriate labelling instructions. A process for producing a powdered dispersible composition is also provided, wherein the process comprises removing the solvent from a solution comprising a solvent, a glass former and a pharmacologically active material under conditions sufficient to form a glassy matrix having the pharmacologically active material within the matrix.
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申请公布号 |
CA2274758(A1) |
申请公布日期 |
1998.04.23 |
申请号 |
CA19972274758 |
申请日期 |
1997.10.14 |
申请人 |
INHALE THERAPEUTIC SYSTEMS |
发明人 |
KUO, MEI-CHANG;FOSTER, LINDA C.;BILLINGSLEY, SHEILA R. |
分类号 |
A61K9/14;A61K9/00;A61K9/12;A61K9/16;A61K9/72;A61K31/70;A61K31/715;A61K38/00;A61K38/23;A61K38/28;A61K38/55;A61K38/57;A61K39/395;A61M11/00;A61M15/00;A61M16/00;A61P5/12;A61P11/00;A61P37/04;(IPC1-7):A61K9/14;A61K31/135;A61K38/38 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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