Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which molecule comprises an antigen and may further comprise immunomodulators such as cytokines and adjuvants. The polynucleotide portion of the conjugate includes at least one immunostimulatory oligonucleotide nucleotide sequence (ISS). Methods of modulating an immune response upon administration of the polynucleotide-immunomodulatory conjugate preparation to a vertebrate host are also disclosed.
申请公布号
WO9816247(A1)
申请公布日期
1998.04.23
申请号
WO1997US19004
申请日期
1997.10.09
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CARSON, DENNIS, A.;RAZ, EYAL;ROMAN, MARK