摘要 |
<p>The invention provides in compounds and compositions for killing both ecto and endo parasites which comprises administering to a warm blooded animal at least a systemically effective amount of an amidine of the formula I: <CHEM> wherein R represents an optionally substituted 5 or 6 member aromatic ring containing at least one nitrogen atom; Y represents an optionally substituted C1-C3 alkylene or alkylidene; A represents a hydrogen, a carbamoyl, a mono or di C1-5 alkyl carbamoyl, a thiocarbamoyl, a mono or di C1-5 alkylthiocarbamoyl, a sulfamoyl, a mono or di C1-5 alkylsulfamoyl, an optionally substituted C1-5 alkyl, an optionally substituted C2-5 alkenyl, an optionally substituted C2-5 alkynyl, an optionally substituted C3-8 cycloalkyl, an optionally substituted C3-8 cycloalkenyl, an optionally substituted aryl or -D-R2, where D is O, S(O)n' CO, CS or CO2 ; n is 0, 1, or 2, and R2 is a hydrogen, an optionally substituted C1-5 alkyl, an optionally substituted C2-5 alkenyl, an optionally substituted C2-5 alkynyl, an optionally substituted C3-8 cycloalkyl, an optionally substituted C3-8 cycloalkenyl, an optionally substituted aryl; Z represents a hydrogen, an optionally substituted C1-5 alkyl, an optionally substituted C2-5 alkenyl, an optionally substituted C2-5 alkynyl, an optionally substituted C3-8 cycloalkyl, an optionally substituted C3-8 cycloalkenyl; B represents a cyano or a nitro; and X represents CH or N; or its salt.</p> |