| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound exhibiting chymase inhibitory activity and antimicrobial activity, thus useful as a therapeutic agent for chronic cardiovascular disturbance or allergic diseases, or as an antimicrobial agent. SOLUTION: This new compound is shown by the formula [R<1> is OH, R<2> is CHO, and R<3> forms a double bond with the carbon atom to which R<1> is bound to, or R<1> is O and R<2> is joined, together with R<3> to form CH(OR<4> ) (R<4> is H or an acyl) or C(=0)], having the following physicochemical characteristics [provided that R<1> is 0; R<2> is joined together with R<3> to form CH(OH)]: appearance: pale yellow needle crystal; solubility: soluble to chloroform, diethyl ether, acetone, ethyl acetate, methanol; sparingly soluble to n-hexane; insoluble to water; melting point: 146-146.5 deg.C; elemental analysis (as C25 H26 O5): C = 73.83 %, H=6.55%; etc. This compound of the formula is obtained by culturing microorganisms belonging to the genus Stachybotrys (e.g. Stachybotrys cylindrospora). |
