| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound which is a group 4 phosphodiesterase inhibitor, useful for treating respiratory diseases. SOLUTION: This compound is shown by formula I (X is CH, O, etc.; R1 is a 1-6C alkyl; R2 is a 3-6C monocyclic hydrocarbon group, a 7-10C hydrocarbon group, etc. ; R is a halogen or a group substituted with R1 , etc.) such as 4-(3- cyclopentyloxy-4methoxybenzyl)-1-(imidazol-4-ylcarbonyl)piperidine. The production of formula I is produced by reacting a cyclic secondary amine of formula II with a carbonyl compound of formula III (Y is hydroxy, Cl, etc.). For example, when Y is Cl in the formula III, the reagents are brought into contact each other in the presence of a tertiary amine (e.g. triethylamine) or a mineral base (e.g. KOH, etc.) in an aprotic solvent at 0-50 deg.C for 1-20 hours by a wellknown method. |
