发明名称 |
Transgenic bovine |
摘要 |
A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.
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申请公布号 |
US5741957(A) |
申请公布日期 |
1998.04.21 |
申请号 |
US19950461333 |
申请日期 |
1995.06.05 |
申请人 |
PHARMING B.V. |
发明人 |
DEBOER, HERMAN A.;STRIJKER, REIN;HEYNEKER, HERBERT L.;PLATENBURG, GERARD;LEE, SANG HE;PIEPER, FRANK;KRIMPENFORT, PAUL J. A. |
分类号 |
A01K67/027;A23C9/20;C07K14/47;C07K14/765;C07K14/79;C12N9/36;C12N9/64;C12N15/12;C12N15/85;(IPC1-7):C12N5/00;C12N15/00;C12P21/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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