发明名称 |
Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
摘要 |
Modulators of neurotransmitter release including substituted guanidines, N''-aminoguanidines, and N,N'N'',N'''-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
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申请公布号 |
US5741661(A) |
申请公布日期 |
1998.04.21 |
申请号 |
US19950463686 |
申请日期 |
1995.06.05 |
申请人 |
CAMBRIDGE NEUROSCIENCE, INC. |
发明人 |
GOLDIN, STANLEY M.;KATRAGADDA, SUBBARAO;HU, LAIN-YEN;REDDY, N. LAXMA;FISCHER, JAMES B.;KNAPP, ANDREW GANNETT;MARGOLIN, LEE DAVID |
分类号 |
A61K31/155;A61K31/37;A61K31/4453;(IPC1-7):C12Q1/02;A23J3/00;A01N37/52 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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