Method for preparing poly (FdU)n

摘要

Homo-oligomeric 5-fluorouridine and 5-fluorodeoxyuridine (FrUn and FdUn, n=oligomer length) are synthesized and used as a polymeric drug delivery system for production of FdUMP, the potent inhibitor of thymidyalte synthase (TS) and an important target in cancer chemotherapy. Disclosed are methods of both preparing and utilizing said compositions.