发明名称 NOVEL SAPONIN AND NA+-K+ ATPASE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT
摘要 NEW MATERIAL:Compounds of formulas I and II. EXAMPLE:13beta,28-Epoxyolean-11-ene-3beta,16 beta,23-triol-3-0-(2,6-0-diacetyl)-B-D- glucopyranosyl-(1 3)-beta-D-fucopyranoside. USE:A Na<+>-K<+> ATPase inhibitor. Useful for treating cardiac failures and atrial arrhythmia. PREPARATION:Bupleurum falcatum L. is extracted with a solvent such as hexane, and the solvent is subsequently removed from the extraction solution. The extracted product is distributed with water and n-hexane, chloroform or water-saturated n-butanol to give an n-butanol extract. The extract is heated to >=100 deg.C under a dry condition and subjected to a column chromatography using hexane, etc., as an extraction solvent.
申请公布号 JPH04159293(A) 申请公布日期 1992.06.02
申请号 JP19900284309 申请日期 1990.10.24
申请人 TSUMURA & CO 发明人 EHATA TAKAFUMI;MORITA MAKOTO;OKUI YUKA;MIHASHI HIROSHI
分类号 C07H17/04;A61K31/70;A61K31/7042;A61K31/7048;A61K36/23;A61P9/06;A61P9/12 主分类号 C07H17/04
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