METHOD FOR STEREOSELECTIVE SYNTHESIS OF ALKYLATED HYDROXYINDOLES AND METHOD FOR PREPARING OPTICALLY PURE ALKYLATED HYDROXYINDOLE ENANTIOMER

摘要

FIELD: organic chemistry; pharmaceutics. SUBSTANCE: stereoselective synthesis of alkylated hydroxyindole resides in reacting racemic-grade hydroxyindole with halogenated acetonitrile under interphase transfer reaction conditions, in presence of chiral catalyst. Mixture of enantiomers is subjected to separation by recrystallization in suitable solvent. EFFECT: higher efficiency. 4 cl, 2 tbl