| 发明名称 |
METHOTREXATE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention proposes compound of the formula: $$$ where $$$ is $$$; $$$ is hydrogen atom, lower alkyl group containing 1-4 carbon atoms or benzyl group; n = 1-4 as a whole number; $$$ is $$$. This compound shows potential antirheumatic activity, carcinostatic property and low toxicity and can be used in medicine for psoriasis treatment. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 8 cl, 15 dwg øøø1
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| 申请公布号 |
RU2109016(C1) |
申请公布日期 |
1998.04.20 |
| 申请号 |
RU19930005141 |
申请日期 |
1991.08.14 |
| 申请人 |
CHUGAI SEJJAKU KABUSIKI KAJSJA |
发明人 |
NOBUKHIRO OKHI;KHIROKHARU MATSUOKA;KATSUKHITO MIJAMOTO;KHIROSI SUZUKI;NOBUAKI KATO;KEJITIRO TSUDZI;JASUKHISA TAKEDA;MASAKHIKO MIKHARA;KHIROMITI NISINA;SIN SIMAOKA;KENITI AKAMATSU;NOBUKHIRO OKHI;KHIROKHARU MATSUOKA;KATSUKHITO MIJAMOTO;KHIROSI SUZUKI;NOBUAKI KATO;KEJITIRO TSUDZI;JASUKHISA TAKEDA;MASAKHIKO MIKHARA;KHIROMITI NISINA;SIN SIMAOKA;KENITI AKAMATSU |
| 分类号 |
C07D475/08;A61K31/505;A61K31/52;A61K31/535;A61K31/536;A61K31/54;A61K31/5415;A61K31/675;A61P35/00;C07D209/04;C07D215/00;C07D239/70;C07D241/36;C07D265/34;C07D279/16;(IPC1-7):C07D475/08;C07D209:04;C07D215:00;C07D239:70;C07D241:36;C07D265:34;C07D279:16 |
主分类号 |
C07D475/08 |
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