发明名称 |
Fremgangsmåde til fremstilling af et 16beta-methylsteroid og nogle intermediære |
摘要 |
<p>Prodn. of 16 beta -methyl-17 alpha -hydroxy- 4,9(11)-pregnadiene-3,20-dione of formula (I) comprises: (a) treating a 17 alpha -hydroxy-17 beta -nitrile with a dehydrating agent to give a 16,17-dehydro-17-nitrile; (b) protecting the oxo gp. if necessary; (c) reacting with an organometallic methylating agent and hydrolysing the resulting imine to give a methyl ketone; (d) treating with an epoxidising agent in a basic medium to give a 16 alpha ,17 alpha -epoxide; (e) protecting the 20-oxo gp.; (f) reacting with an organometallic methylating agent to give a 16 beta -methyl deriv.; and (g) deprotecting the oxo gps. to give (I).</p> |
申请公布号 |
DK0685487(T3) |
申请公布日期 |
1998.04.20 |
申请号 |
DK19950401273T |
申请日期 |
1995.06.01 |
申请人 |
ROUSSEL-UCLAF |
发明人 |
VIVAT, MICHEL;GEURTS, CATHERINE |
分类号 |
C07J5/00;C07J7/00;C07J13/00;C07J21/00;C07J41/00;C07J71/00;(IPC1-7):C07J7/00 |
主分类号 |
C07J5/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|