发明名称 |
POLYPEPTIDE CAPABLE OF INTERACTING WITH THROMBIN |
摘要 |
Disclosed is a substantially pure polypeptide having a specific amino acid sequence containing (a) an amino acid residue selected from the group consisting of Asp, Glu and Gla wherein Gla represents a y-carboxyglutamic acid residue or (b) a peptide or polypeptide residue consisting of at least two amino acid residues selected from Asp, Glu and Gla, wherein the above-mentioned at least two amino acid residue are all the same or combinations of the Asp, Glu and Gla. The polypeptide is capable of interacting with thrombin to form a binding therebetween, thereby exhibiting an activity to inhibit the blood coagulation and platelet aggregation by thrombin and/or an activity to promote the thrombin-catalyzed activation of protein C. This novel polypeptide has a low molecular weight so that it is suitable for oral or nasal administration.
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申请公布号 |
CA2048425(C) |
申请公布日期 |
1998.04.21 |
申请号 |
CA19912048425 |
申请日期 |
1991.08.05 |
申请人 |
ASAHI KASEI KOGYO KABUSHIKI KAISHA |
发明人 |
ZUSHI, MICHITAKA;GOMI, KOMAKAZU;YAMAMOTO, SHUJI;MATSUDA, AKIO;SUZUKI, KOJI |
分类号 |
C07K14/745;C12N1/15;C12N15/12;C12N15/80;(IPC1-7):C12N15/12;C12N5/10;A61K38/36 |
主分类号 |
C07K14/745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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