| 摘要 |
2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives represented by general formula (I) or their salts and medicinal compositions containing these derivatives or salts thereof together with pharmaceutically acceptable carriers, wherein R<1> and R<2> are the same or different and each represents hydrogen, halogeno, hydroxy, lower alkyl, halogenated lower alkyl, (lower alkyl)-O-, nitro, cyano, amino, oxopyrrolidinyl, (lower alkyl)-O-CO-NH-, (lower alkyl)-CO-NH- or (lower alkyl)-SO2-NH-, or R<1> and R<2> may together form -O-(lower alkylene)-O-; R<3> and R<4> represent each hydrogen, or R<3> and R<4> may together form oxo; X represents a single bond, oxygen or sulfur; A represents lower alkylene; and the ring B represents an optionally substituted hydrocarbon ring or an optionally substituted heterocycle which may be bonded to a benzene ring. These compounds have a current If inhibitory effect and are useful as heart rate depressants in the prevention or treatment of, in particular, ischemic cardiac diseases such as angina pectoris (thoracic angina pectoris) and myocardial infarction and circulatory diseases such as congestive heart failure and irregular pulse (supraventricular irregular pulse, etc.). |
