发明名称 |
TARGETED ADDITION OF SOLUBLE POLYMERS TO RECOMBINANT PROTEINS |
摘要 |
Proteins are modified with soluble polymers to change their biological properties, such as to render them less immunogenic and longer-lived in the body. The modification is by a strong, but non-covalent complexation between a metal chelate and an oligohistidine tag which is engineered into the protein. This method of protein modification leads to homogeneous preparations which can be readily prepared in large quantities. |
申请公布号 |
WO9815293(A2) |
申请公布日期 |
1998.04.16 |
申请号 |
WO1997US18104 |
申请日期 |
1997.10.07 |
申请人 |
ADVANCED GENETIC TECHNOLOGY CORPORATION |
发明人 |
SEED, BRIAN;SHAO, WEN;SEED, JOHN |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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