This application relates to the use of attenuated prokaryotic microorganism strains (such as Salmonella) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and the associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of an HPV including a fusion partner and that tumor protection can be induced.
申请公布号
WO9815631(A1)
申请公布日期
1998.04.16
申请号
WO1997GB02740
申请日期
1997.10.07
申请人
FONDATION POUR LE PERFECTIONNEMENT ET LA RECHERCHE;KIDDLE, SIMON, JOHN;HAEFLIGER, DENISE, NARDELLI;KRAEHENBUHL, JEAN-PIERRE