| 摘要 |
This invention is directed to methods for treatment of non-insulin-dependent diabetes mellitus, for reducing blood glucose levels, or hyperglycemia. The methods entail administering to a mammal in need of such treatment a therapeutically effective amount of a composition whose active ingredient consists essentially of a compound of structure (I) or a pharmaceutically acceptable salt thereof. In the compound R and R' are independently H or a C1-C20 alkyl or C2-C20 alkenyl group which may be substituted or unsubstituted. Alternatively, R and R' are such that together a cycloalkyl or cycloalkenyl ring is formed. In the chain linking the two phenolic derivatives each of (C(R)=C(R')) or (C(R)(R')) are the same or different. A and A' are independently C2-C20 acylamino, C2-C20 acyloxy, C2-C20 alcanoyl, C2-C20 alkoxycarbonyl, C1-C20 alkoxyl, C1-C20 alkylamino, C2-C20 alkyl carboxyl, amino, C2-C20 carbalkoxyl, carboxyl, cyano, halo, hydroxy. B and B' are independently H, C2-C20 alkanoyl, C3-C20 alkenoyl, C2-C20 alkenyl, C2-C20 alkoxycarbonyl, C1-C20 alkyl, aroyl, aralkanoyl, C2-C20 carbamoyl, or phosphate. The invention is also directed to methods of treatment using a bisphenolic compound in conjunction with another hypoglycemic or hypolipidemic agent.
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