New pentaerythritol nitrate ester derivatives

摘要

Nitrate esters of formula (I)-(III), their salts and compounds of formula (IV) are new. In (I), R1-R3 = H, OR6, ONO2, OR4 or R5; R4 = COR6 or R10; R5 = PO4R7, PO4R9, SO3R9 or COOR6; R6 = H or 1-6C alkyl; R7 = 1-6C alkylene-R8; R8 = N(R6)2, N<+>(R6)3 or N<+>(R6)3 X<->; R9 = R6, aryl or N(R6)2; R10 = a 3- or 5-carbonyl residue of a 2,4 and/or 6-optionally substituted 1,4-dihydropyridine-3,5-dicarboxylic acid; 1-substituted pyrrolidine-2-carbonyl group; an N-carbonyl residue of a substituted sydnoneimine; CO-CH(NHCOR6)-C(R6)2-S-NO; CO-CH(NH2)-C(R6)2-S-NO or NH-CH(COOR6)-C(R6)2-S-NO; X = halogen or an anion-forming group. The following combinations ar excluded: R1-R3 = ONO2; R1 = OH and R2, R3 = ONO2; R1 = R2 = OH and R3 = ONO2; and R1-R3 = OH. In (II), R11 = NO2 acyl, alkyl or alkenyl. In (III), R12 = NO2 or as for R4-R10; n = 0-10. In (IV), each Q is the same and is OH or ONO2.