发明名称 3-£4-(1-SUBSTITUTED - 4 PIPERAZINYL)BUTYL-4- THIAZOLIDINONE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
摘要 There are disclosed compounds of the formula, <CHEM> where n is 0 or 1; A is <CHEM> where X, Y, Z, U, V, W, Q, S and T are each hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano or trifluoromethyl; m is 1 or 2; R1 and R2 are independently hydrogen, loweralkyl or aryl, or alternatively R1 + R2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring; R3 and R4 are independently hydrogen or loweralkyl, or alternatively R3 + R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluormethyl, and a process for their preparation. The compounds are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.
申请公布号 KR0130976(B1) 申请公布日期 1998.04.16
申请号 KR19880015210 申请日期 1988.11.18
申请人 HOECHST-RUSSEL PHARMACEUTICALS INC. 发明人 HRIB, NICHOLAS J.;JURCAK, JOHN G.
分类号 A61K31/425;A61K31/44;A61K31/47;A61K31/495;A61K31/505;A61P25/04;A61P25/08;A61P25/18;A61P25/20;A61P25/24;A61P25/26;C07D277/14;C07D277/60;C07D277/82;C07D417/12;C07D417/14;C07D513/10;(IPC1-7):C07D401/06 主分类号 A61K31/425
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