| 摘要 |
<p>Proteins are modified with soluble polymers to change their biological properties, such as to render them less immunogenic and longer-lived in the body. The modification is by a strong, but non-covalent complexation between a metal chelate and an oligohistidine tag which is engineered into the protein. This method of protein modification leads to homogeneous preparations which can be readily prepared in large quantities.</p> |
