METHODS AND COMPOSITIONS FOR INDUCING A PROTECTIVE IMMUNE RESPONSE TO CANCERS

摘要

Methods for inducing an immune response to a tumor cell are disclosed for use in the regression of existing tumors and in the prevention of cancers, especially in high risk subjects with familial histories. Compositions for use in these methods include particularly, DNA vaccines or recombinant viruses which contain a p53 gene which encodes a biologically inactive form of p53 incapable of tetramerization, or which contain a gene encoding a p53 antigen fused to a signal sequence which retargets the protein to preferred cellular compartments. The methods and compositions are further enhanced by co-administration of one or more chemokine, cytokine or combinations thereof.