Human interferon-Beta2A for use as a medicament

摘要

Human interferon-beta<Sub>2A</Sub> and interferon-beta<Sub>2B</Sub> are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN-β<Sub>2A</Sub> and IFN-β<Sub>2B</Sub>, respectively. The sequence of IFN-β<Sub>2A</Sub> cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN-β<Sub>2A</Sub> and IFN-β<Sub>2B</Sub>. The antiviral activity of such recombinant IFN-β<Sub>2A</Sub> and IFN-β<Sub>2B</Sub> is demonstrated as well as other biological activity identifying them as human interferons. It has been shown that IFN-β<Sub>2</Sub> secretion is induced in human cells by growth-stimulatory cytokines.

IFN-β<Sub>2A</Sub> may be used as a medicament for influencing cell growth and differentiation. IFN-β<Sub>2A</Sub> may also be useful during terminal differentiation of cancer cells.