| 发明名称 |
VARIANTS OF p53 PROTEIN AND THEIR THERAPAUTICAL APPLICATION |
| 摘要 |
<p>Proteins derived from the product of tumor suppressor gene p53 and having enhanced functions for therapeutical use are disclosed. The proteins advantageously have enhanced tumour suppressor and programmed cell death inducer functions, particularly in proliferative disease contexts where wild-type p53 protein is inactivated. Nucleic acids coding for such molecules, vectors containing same, and therapeutical use thereof, particularly in gene therapy, are also disclosed.</p> |
| 申请公布号 |
CZ9800144(A3) |
申请公布日期 |
1998.04.15 |
| 申请号 |
CZ19980000144 |
申请日期 |
1996.07.17 |
| 申请人 |
RHONE-POULENC RORER S. A. |
发明人 |
CONSEILLER EMMANUEL;BRACCO LAURENT |
| 分类号 |
C12N15/09;A61K31/00;A61K35/76;A61K38/00;A61K48/00;A61P9/00;A61P9/14;A61P35/00;A61P43/00;C07K14/82;C12N15/12;C12P21/02;C12R1/91;(IPC1-7):C12N15/12;C07K19/00;C12N15/62;A61K31/70;A61K38/16;C12N15/86 |
主分类号 |
C12N15/09 |
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