| 发明名称 |
DERIVATIVE OF 1,25-DIHYDROXY-16,22,23-TRISDEHYDROCHOLECALCIPHEROL, PROCESS OF ITS PREPARATION, INTERMEDIATE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
| 摘要 |
<p>The invention relates to a compound of the formula <CHEM> wherein R is hydroxy and R<1> is H2 or CH2, or R is hydrogen or fluoro and R<1> is CH2. Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases, such as psoriasis, neoplastic diseases, such as leukemia, and sebaceous gland diseases, such as acne and sebhorreic dermatitis.</p> |
| 申请公布号 |
CZ9700858(A3) |
申请公布日期 |
1998.04.15 |
| 申请号 |
CZ19970000858 |
申请日期 |
1997.03.20 |
| 申请人 |
F. HOFFMANN - LA ROCHE AG |
发明人 |
HENNESSY BERNARD MICHAEL;IACOBELLI JEROME ANTHONY;USKOKOVIC MILAN RADOJE |
| 分类号 |
A61K31/59;A61P17/00;A61P35/00;A61P35/02;C07C401/00;C07F7/18;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
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