Methods of enhancing antigen-specific T cell responses

摘要

PCT No. PCT/US94/04367 Sec. 371 Date Jul. 29, 1996 Sec. 102(e) Date Jul. 29, 1996 PCT Filed Apr. 20, 1994 PCT Pub. No. WO94/24267 PCT Pub. Date Oct. 27, 1994Recombinant polynucleotides are provided that confer at least partial immunity on an individual to an infectious intracellular pathogenic agent. The recombinant polynucleotides encode a costimulatory factor and/or a target antigen polypeptide. The immune response that confers the immunity results from the expression of both polypeptides in an antigen presenting cell in the individual. The immunity is to the pathogenic agent that naturally encodes the target antigen polypeptide.