| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the novel subject compound which is useful for the treatment of arthritis as a matrix metal proteinase inhibitor or a tumor necrosis factor production inhibitor. SOLUTION: This compound is represented by formula I the broken line represents an arbitrary double bond; n is 0, 1, 2; p is 0 or 1; q is 0, 1, 2; X, Y, Z are each CR<1> R<2> [R<1> and R<2> are each H, a (substituted) 1-6C alkyl]; Ar is a 6-10 aryl, a 5-9 heteroaryl}, typically N-hydroxy-3-(4-phenoxy- benzenesulfonyl)-bicycle[2, 2.,2]octance-2-carboxamide. In order to this compound, for example, an arylsulfonyl chloride of formula II is allowed to react with sodium iodide in an aprotic solvent such as acetone at room temperature for about 12-18 hours to convert to the corresponding sodium arylsulfinate.</p> |
