Enzymatic hydrolysis method for the preparation of C-13 hydroxyl-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes

摘要

An enzymatic hydrolysis method for the preparation of compounds useful as intermediates in the preparation of taxanes such as taxol, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups.