| 摘要 |
PROBLEM TO BE SOLVED: To obtain a vasodepressing agent having a high saftely and capable of being used for medicines effective in a microdose through an oral administration and derived from natural sources, specific sanitary foods, healthy foods, etc., and provide its production. SOLUTION: This vasodepressing agent contains dipeptide Tyr-Pro or its salt as an effective ingredient and administered in 0.05-10mg/kg body weight.day as an effective dose. This production of the vasodepressing agent is to culture lactic bacteria of the genus Bacillus such as Lactobacillus helveticus, etc., in a medium containing a peptide and/or a protein containing a Try-Pro amino acid arrangement, obtain a culture solution containing Tyr-Pro dipeptide, if needed, centrifuge the culture solution and purify the supernatant with a reverse phase resin. |
