发明名称 |
CC-1065 analogs |
摘要 |
This invention provides some new synthetically obtained compounds of formula I and II <IMAGE> I <IMAGE> II which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests. In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.
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申请公布号 |
US5739350(A) |
申请公布日期 |
1998.04.14 |
申请号 |
US19950479231 |
申请日期 |
1995.06.07 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
KELLY, ROBERT C.;MITCHELL, MARK A.;ARISTOFF, PAUL A. |
分类号 |
A61K31/40;A61K38/00;A61K47/48;A61P31/12;A61P35/00;C07D487/04;C07D487/10;C07F9/6561;C07K1/113;C07K5/06;C07K5/062;C07K5/08;C07K16/00;C07K17/06;(IPC1-7):C07D487/08 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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