发明名称 |
Antitussive agents |
摘要 |
PCT No. PCT/JP94/01047 Sec. 371 Date Apr. 27, 1995 Sec. 102(e) Date Apr. 27, 1995 PCT Filed Jun. 28, 1995 PCT Pub. No. WO95/01178 PCT Pub. Date Jan. 12, 1995There are provided novel antitussive agents different from existing antitussive agents or those under development. Antitussive agents containing morphinan derivatives represented by compound 6:id-addition salts thereof and those derivatives or their salts as effective components. The antitussive agents according to the present invention have strong antitussive effects as highly selective kappa -opioid agonists, and may thus be applied as useful antitussive agents in the prophylaxis and treatment of coughing in a patient in need thereof.
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申请公布号 |
US5739145(A) |
申请公布日期 |
1998.04.14 |
申请号 |
US19950393020 |
申请日期 |
1995.04.27 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
NAGASE, HIROSHI;KAWAI, KOJI;ENDOH, TAKASHI;UENO, SHINYA;NEGISHI, YUJI |
分类号 |
A61K31/47;A61K31/485;(IPC1-7):A61K31/47;C07D221/28;C07D489/00 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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