发明名称 TRANS-SODIUM CROCETINATE, METHODS OF MAKING AND METHODS OF USE THEREOF
摘要 The use of crocetin has been demonstrated to be effective in elevating oxygen diffusivity, and increasing oxygen consumption by the body tissues of a mammal. Crocetin is difficult to solubilize. Sodium crocetinate, formed by reacting crocetin with sodium hydroxide, appears in several isomeric forms. The trans isomer is effective in improving oxygen diffusivity, while the related cis isomer appears not to be, as seen in the figure. Isolated TSC can be used in place of crocetin, treat a variety of conditions, including hypertension, cardiovascular disease, hemorrhagic shock, papillomas, and related conditions.
申请公布号 WO9814183(A1) 申请公布日期 1998.04.09
申请号 WO1997US17310 申请日期 1997.10.02
申请人 THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION 发明人 GAINER, JOHN, L.
分类号 A61K31/202;C07C57/13;(IPC1-7):A61K31/13;A61K31/20;A61K31/70;C07C57/00;C11B7/00 主分类号 A61K31/202
代理机构 代理人
主权项
地址