| 摘要 |
<p>The invention relates to a method for treating a solid tumor in somatic tissue, or treating or preventing metastasis of such a tumor, in a patient comprising administering to the patient an amount of one or more antigens specific to the somatic tissue effective to induce an immune response against the somatic tissue. In distinction to the above-described immunotherapies, the antigen or antigens administered to the patient are not specific to the tumor, but are specific to the somatic tissue from which the tumor originated. Tissue specific antigens (TSAs) are expected to be more immunogenic than TSTAs and are more numerous. As such, the therapy of the invention has the advantage of initiating and sustaining a strong immune response against the somatic tissue and tumor until the tumor has been rejected. The therapy also has the advantage of eliciting an immune response against metastatic cancer. In another embodiment, the invention relates to vaccines comprising the tissue specific antigen in a pharmaceutically acceptable carrier and in a size and manner to elicit a class I MHC immune response. In another embodiment, the invention relates to a method for the identification and isolation of a tissue specific antigen which can elicit or induce a class I MHS response.</p> |
