Polypeptide than binds to CD30 without cell activation

摘要

Method for suppressing unchecked proliferation, tumour formation and metastasis of cells expressing CD30 antigen, uses a molecule (I) that specifically binds to CD30 without inducing cell activation by CD30. Also claimed is (I), which is a polypeptide with the following amino acid sequence: MAQVQLQQSGAELARPGASV KMSCKASGYTFTTYTIHWVR QRPGHDLEWIGYINPSSGYS DYNQNFKGKTTLTADKSSNT AYMQLNSLTSEDSAVYYCAR RADYGNYEYTWFAYWGQGTT VTVSSGGGGSGGGGSGGGGS DIELTQSPKFMSTSVGDRVN VTYKASQNVGTNVAWFQQKP GQSPKVLIYSASYRYSGVPD RFTGSGSGTDFTLTISNVQS EDLAEYFCQQYHTYPLTFGG GTKLEIKR.