发明名称 |
T CELLS MEDIATING AN IMMUNE RESPONSE AND METHODS OF USE |
摘要 |
The present invention is directed to T cells, compositions, and methos of obtaining and using the same, including and not limited to methods of treating cancer. The methods of the present invention include inter alia: a method of generating T cells capable of infiltrating a tumor of a human and participating in an immune response against the tumor; and a method of treating cancer comprising administering to a human afflicted with a tumor a therapeutically effective amount of T cells that mediate tumor regression, the T cells having been either isolated from the tumor of the human after immunization of the human with a composition comprising hapten-modified tumor cells and/or expanded in vitro from T cells thus isolated.
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申请公布号 |
CA2242590(A1) |
申请公布日期 |
1998.04.09 |
申请号 |
CA19972242590 |
申请日期 |
1997.10.02 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
SENSI, MARIALUISA;ANICHINI, ANDREA;PARMIANI, GIORGIO;BERD, DAVID |
分类号 |
A61K38/00;A61K39/00;C07K14/47;G01N33/574;(IPC1-7):C12N5/08;A61K35/14;A61K39/385;C07K7/06;C07K7/08;C07K14/725;C12Q1/02;C12Q1/68;G01N33/566 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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